Book Chapter

Development of Neural Activity in the Enteric Nervous System: Similarities and Differences to Other Parts of the Nervous System

Marlene M Hao

ENTERIC NERVOUS SYSTEM: 30 YEARS LATER | Advances in Experimental Medicine and Biology | SPRINGER INTERNATIONAL PUBLISHING AG | Published : 2016


All the neurons and glia of the enteric nervous system (ENS) arise from neural crest-derived cells that migrate into the gastrointestinal (GI) tract during development (Yntema and Hammond 1954; Le Douarin and Teillet 1973). Most of the ENS originates from vagal neural crest cells (NCCs), which arise from the caudal hindbrain region of the neural tube, adjacent to somites 1-7. In the developing mouse, vagal NCCs migrate into the developing oesophagus and stomach at embryonic day (E)9.5, enter the small intestine at E10.5, and colonise the developing GI tract in a rostral-to-caudal wave, reaching the anal end of the colon at E14.5 (Serbedzija et al. 1991; Kapur et al. 1992; Anderson et al. 200..

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University of Melbourne Researchers