Journal article

The testis as a major source of circulating inhibins in the male equine fetus during the second half of gestation

Y Tanaka, H Taniyama, N Tsunoda, H Shinbo, N Nagamine, Y Nambo, S Nagata, G Watanabe, CB Herath, NP Groome, K Taya

JOURNAL OF ANDROLOGY | AMER SOC ANDROLOGY, INC | Published : 2002

Abstract

Immunolocalization of the inhibin (a) and inhibin/activin (beta3A and betaB) subunit proteins in equine fetal testes was investigated to determine the ability of the fetal testis to produce inhibins at 120, 150, 200, and 250 days of gestation. In addition, concentrations of immunoreactive (ir)-inhibin, inhibin pro-aC, and inhibin A in both the maternal and fetal circulation were measured. It was found that plasma concentrations of ir-inhibin, inhibin pro-alphaC, and inhibin A were much higher (P < .05) in the fetal than in the maternal circulation at any stage of gestation examined. Similarly, while fetal testicular homogenate contained increased amounts of inhibins, the inhibins were undete..

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