Journal article
The aryl hydrocarbon receptor controls cell-fate decisions in B cells
B Vaidyanathan, A Chaudhry, WT Yewdell, D Angeletti, WF Yen, AK Wheatley, CA Bradfield, AB McDermott, JW Yewdell, AY Rudensky, J Chaudhuri
Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2017
DOI: 10.1084/jem.20160789
Abstract
Generation of cellular heterogeneity is an essential feature of the adaptive immune system. This is best exemplified during humoral immune response when an expanding B cell clone assumes multiple cell fates, including class-switched B cells, antibody- secreting plasma cells, and memory B cells. Although each cell type is essential for immunity, their generation must be exquisitely controlled because a class-switched B cell cannot revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute to the memory pool. In this study, we show that an environmental sensor, the aryl hydrocarbon receptor (AhR) is highly induced upon B cell activation and serves a critic..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH; 1RO1AI072194 and 1RO1AI124186) and the Starr Cancer Research Foundation (I7-A767) to J. Chaudhuri, grants from the Ludwig Center at Memorial Sloan Kettering Cancer Center, the Hilton-Ludwig Cancer Prevention Initiative (Conrad N. Hilton Foundation and Ludgwig Cancer Research), and the Howard Hughes Medical Institute to A.Y. Rudensky, an NIH/National Cancer Institute Cancer Center Support Grant (P30 CA008748) to A.Y. Rudensky and J. Chaudhuri, a grant from the Division of Intramural Research, NIAID, NIH to J.W. Yewdell and A.B. McDermott, a grant from the Intramural Research Program of the Vaccine Research Center, NIAID, NIH to A.B. McDermott, and a grant from the NIH (R37-ES005703) to C.A. Bradfield.