EFFECTS OF MANNITOL OR FUROSEMIDE DIURESIS ON CIS-DICHLORODIAMMINE-PLATINUM(II) ANTI-TUMOR ACTIVITY AND TOXICITY TO HOST-RENEWING CELL-POPULATIONS IN RATS

Abstract

Administration of mannitol (300 mg in 3.0 ml 0.45% NaCI solution as a 30-min i.v. infusion) but not furosemide (12.5 mg/kg i.p. with 6.0 ml 0.9% NaCI solution significantly reduced acute (14-day) lethality in normal male F344 rats given cis-dichlorodiammineplatinum(II) (CDDP) (8.5 mg/kg i.v.). Because both diuretics protected rats from CDDP impairment of renal function and because a 30-min i.v. infusion of 3.0 ml 0.45% NaCl solution with CDDP (8.5 mg/ kg) resulted in lower blood urea nitrogen levels but did not reduce mortality in F344 rats, it was concluded that prevention of acute lethality with mannitol was not directly related to protection of renal function. Other tissues, particularly ..