Journal article

COMPARATIVE BIOLOGY OF MOUSE AND HUMAN EMBRYONAL CARCINOMA

MF PERA, S ROACH, CJ ELLISS

CANCER SURVEYS | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 1990

Abstract

The biology of human germ cell neoplasia has been the subject of increasing investigation during the past decade. The objectives of such investigations include better understanding of the pathogenesis of the diseases, improvement in patient management, and insights into cancer cell differentiation and human development. Many of the approaches to human germ cell tumour biology have been strongly influenced by work in the mouse. Here we review some comparative aspects of germ cell tumours in mouse and man. There are striking differences between the two species in the mechanisms of tumour development, the role of genetic background in tumour susceptibility, the cytogenetics of the tumours, and ..

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University of Melbourne Researchers