Journal article
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
S Infantino, A Light, K O'donnell, V Bryant, DT Avery, M Elliott, SG Tangye, G Belz, F Mackay, S Richard, D Tarlinton
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
Abstract
PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
Grants
Awarded by Australian Research Council
Funding Acknowledgements
We thank members of the Tarlinton lab for critical review of the manuscript, discussion and general technical assistance. This work is supported by a National Health and Medical Research Council (NHMRC) Australia program grant to D.T. and G.B. (1054925). S.I. was supported by a DRFG Fellowship, D.T. by an NHMRC Research Fellowship and G.B. by an Australian Research Council Future Fellowship. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.