Journal article

AN ANTIHYPERTENSIVE ACTION OF PROPRANOLOL IN DOCA/SALT‐TREATED RATS

GJ Dusting, MJ Rand

Clinical and Experimental Pharmacology and Physiology | Published : 1974

Abstract

SUMMARY 1. The cardiovascular effects of acute and long‐term (4–7 weeks) treatment with propranolol and guanethidine were observed in conscious, DOCA/salt‐treated hypertensive rats. 2. During long‐term treatment with a low dose of propranolol (0.2 mg/kg, subcutaneously, twice daily), the blood pressure is reduced to normotensive levels. 3. The subcutaneous injection of 0.2 mg/kg of propranolol lowers blood pressure and heart rate for 2–4 h at the start of long‐term treatment, but these acute effects become less as treatment continues. 4. Long‐term treatment with a high dose of propranolol (5 mg/kg, subcutaneously, twice daily) reduces heart rate but not blood pressure. 5. The acute effects o..

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