Elimination of prostacyclin (PGI2) and 6‐oxo‐PGF1α in anaesthetized dogs

Abstract

The plasma concentration of 6‐oxo‐PGF1α was measured by radioimmunoassay after constant rate infusion of 6‐oxo‐PGF1α or prostacyclin (PGI2) into anaesthetized dogs. A steady‐state plasma concentration was rapidly attained with both compounds. After termination of the infusions, the concentration of 6‐oxo‐PGF1α declined according to a bi‐exponential process. The steady‐state plasma concentrations of 6‐oxo‐PGF1α obtained after infusion of 6‐oxo‐PGF1α and PGI2 were approximately 10 times higher than the corresponding steady‐state level of PGF2α measured after infusion of PGF2α into the same dogs. The data presented suggest that PGI2 and 6‐oxo‐PGF1α are eliminated more slowly than PGF2α, probabl..