A specific increase in cardiovascular reactivity related to sodium retention in DOCA-salt-treated rats.
GJ Dusting, GS Harris, MJ Rand
Clin Sci Mol Med | Published : 1973
Exchangeable body sodium was measured in deoxycorticosterone acetate (DOCA) salt treated rats by whole body γ counting after equilibration with a 22Na isotope. The blood pressure of DOCA salt treated rats is positively correlated with their exchangeable body sodium. After pithing, the heart rate is significantly lower in DOCA salt treated than in control rats: in conscious DOCA salt treated rats the heart rate is also lower than in control rats but the difference was not statistically significant. Cardiac and vascular responses to sympathetic stimulation are positively correlated with exchangeable body sodium in pithed rats, but there is no correlation between either cardiac or vascular resp..View full abstract