Angiotensin-induced release of a prostacyclin-like substance from the lungs.
J Cardiovasc Pharmacol | Published : 1981
Intravenous infusions of angiotensins I and II into anesthetized dogs caused release of a prostacyclin-like substance into arterial blood: prostacyclin (PGI2) was detected by direct bioassay on bovine coronary artery, rat stomach strip, and rat colon, all of which were treated with phenoxybenzamine, propranolol, and Sar1-Ile8-angiotensin II. This effect of angiotensin I, but not of angiotensin II, was abolished by captopril (1 mg/kg, i.v.), and the effect of angiotensin II was abolished by Sar1-Ala8-angiotensin II (0.5 micrograms/kg/min, i.v.). The PGI2-like substance disappeared during incubation of arterial blood for 6 min, and much less appeared in mixed venous blood withdrawn from the ri..View full abstract