Inhibition of vasoconstrictor mechanisms by dazoxiben in the rat mesenteric vasculature.
DM Li, RM De Garis, GJ Dusting
Eur J Pharmacol | Published : 1985
Sympathetic neurotransmission can be modulated by prostaglandins in a number of tissues, but it is not known whether thromboxane A2 also influences neurotransmission. In this study, vasoconstrictor responses to electrical stimulation of the sympathetic nerves and to injection of noradrenaline were examined in the blood perfused mesentery of the rat in situ. The thromboxane synthetase inhibitor dazoxiben, infused into the perfusion circuit at 10-100 mumol/l, significantly inhibited constrictor responses to nerve stimulation and to injected noradrenaline and vasopressin. The cyclo-oxygenase inhibitor indomethacin (28 mumol/kg intravenously) had no effect on responses to nerve stimulation or no..View full abstract