STIMULATION BY ANGIOTENSIN OF PROSTACYCLIN BIOSYNTHESIS IN RATS AND DOGS

Abstract

1. Stimulation of prostanoid release by angiotensins (AI and All) in rat isolated mesenteric vasculature and in the circulation of anaesthetized dogs has been investigated by bioassay. 2. AI and All released a PGI2‐like substance into rat mesenteric effluent and arterial blood of dogs; PGE2, PGF2α or TXA2 were not detected. 3. AI stimulated PGL release in both systems largely as a result of its conversion to All, since PGI2 release was much reduced after treatment with captopril. 4. Intravenous AII (0‐2‐1.0μg kg−1min−1) in dogs released PGI2 mainly from the lungs since right atrial blood contained much less than arterial blood. 5. Indomethacin (1 μg/ml) abolished All‐induced PGI2 release fro..