Journal article

The endogenous nitrovasodilator produced by the vascular endothelium.

GJ Dusting, PS Macdonald, EA Higgs, S Moncada

Aust N Z J Med | Published : 1989


The calibre of blood vessels and the tone of the vascular smooth muscle are determined not only by innervation, circulating hormones and metabolic factors, but also by local mediators generated in the vascular wall. Prostacyclin is produced mainly by the endothelium; it was the first endothelium‐derived mediator that aroused widespread attention, for it is a powerful vasodilator and inhibitor of platelet aggregation.1 More recently it was discovered that the vascular endothelium produced another potent humoral agent which is responsible for the vasodilator action of many endogenous substances. This substance is endothelium‐derived relaxing factor (EDRF). Copyright © 1989, Wiley Blackwell. Al..

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