Continuous extradural infusion of ropivacaine for prevention of postoperative pain after major orthopaedic surgery.
G Turner, D Blake, M Buckland, D Chamley, P Dawson, C Goodchild, J Mezzatesta, D Scott, A Sultana, S Walker, M Hendrata, P Mooney, M Armstrong
British Journal of Anaesthesia | Published : 1996
We studied 151 patients undergoing total hip or knee arthroplasty, or cruciate ligament reconstruction in a multicentre study in Australia and New Zealand. Patients were openly allocated randomly to one of five treatment groups or to a control group. General anaesthesia was induced after introduction of extradural block with 0.5% ropivacaine. After surgery, patients received an extradural infusion of 0.2% ropivacaine at 6, 8, 10, 12 or 14 ml h-1 or received no postoperative extradural infusion (control group). All patients had access to i.v. PCA morphine for supplementary analgesia. Morphine consumption was lower in all treatment groups compared with the control group, decreasing with increa..View full abstract