Evaluation of the effects of urotensin ii and soluble epoxide hydrolase inhibitor on skin microvessel tone in healthy controls and heart failure patients

Abstract

Introduction: Urotensin II (UII) is a potent vasoactive peptide that exerts differential effects on heart failure (HF) patients compared to health controls. However, the mechanism of action remains unclear. The role of soluble epoxide hydrolase (sEH) as a mediator of UII in the vasculature has not been explored. Aims: The aim of this study was to examine the effect of UII in the presence and absence of sEH inhibitor AUDA on skin microvessel tone in HF patients and healthy controls using iontophoresis and laser Doppler velocimetry. UII (10-7M) and AUDA (10-10, 10-7, and 10-5M) were administered to the forearm of participants by iontophoresis for 30 seconds. Laser Doppler velocimetry was perfo..