Journal article

DETECTION OF CIRCULATING TUMOR-CELLS IN COLORECTAL-CANCER BY IMMUNOBEAD-PCR IS A SENSITIVE PROGNOSTIC MARKER FOR RELAPSE OF DISEASE

JE HARDINGHAM, D KOTASEK, RE SAGE, MC EATON, VH PASCOE, A DOBROVIC

MOLECULAR MEDICINE | BLACKWELL SCIENCE PUBL INC CAMBRIDGE | Published : 1995

Abstract

BACKGROUND: Recurrent and metastatic carcinoma of the colorectum remains a major problem, with survival at 5 years post curative resection still only about 50%. Moreover, up to 30% of patients who present with early stage disease also relapse and die within 5 years, suggesting the presence of micrometastatic disease at diagnosis. One route of metastatic spread is via the blood stream, hence the detection of tumor cells in blood is likely to provide an important predictive tool with respect to relapse of disease. We have developed a sensitive molecular technique to identify tumor cells in blood using mutations in codon 12 of the K-ras gene as a marker. MATERIALS AND METHODS: Twenty-seven pati..

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University of Melbourne Researchers