Journal article

SIGNIFICANCE OF MOLECULAR MARKER-POSITIVE CELLS AFTER AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION FOR NON-HODGKINS-LYMPHOMA

JE HARDINGHAM, D KOTASEK, RE SAGE, LT GOOLEY, JX MI, A DOBROVIC, JE NORMAN, AE BOLTON, BM DALE

JOURNAL OF CLINICAL ONCOLOGY | W B SAUNDERS CO | Published : 1995

Abstract

PURPOSE: To evaluate the significance of molecular marker-positive cells in a cohort of non-Hodgkin's lymphoma (NHL) patients undergoing high-dose chemotherapy and autologous peripheral-blood stem-cell transplantation (PBSCT). PATIENTS AND METHODS: Twenty-eight PBSC transplants have been performed in 24 patients with poor-prognosis NHL. Molecular analysis of the t(14;18) (q32;q21) translocation (bcl-2/immunoglobulin [Ig] heavy-chain joining locus [JH] fusion) or antigen receptor gene rearrangements was performed to determine the presence of lymphoma cells at presentation, in PBSC harvests, and before and after autologous PBSCT. Kaplan-Meier estimates of survival and Cox regression analyses w..

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