Journal article

HEMATOPOIETIC COLONY-STIMULATING FACTORS

NA NICOLA, M VADAS

IMMUNOLOGY TODAY | ELSEVIER SCI LTD | Published : 1984

Abstract

Hemopoietic colony-stimulatingfactors (CSFs) are glycoproteingrowth factors produced by many tissues in the body; they are essential for the survival, growth and differentiation of hemopoietic progenitor cells in vitro. In this article Nicos Nicola and Mathew TTadas discuss the classes of CSF that have now been purified (M-CSF, GM-CSF, G-CSF and Multi-CSF). Each is active in vitro at picomolar concentrations, but each can be distinguished from the others by its unique molecular properties and unique spectrum of biological activity. In addition to their proliferative effects, these regulators also appear able to stimulate functional activities in mature hemopoietic cells.

University of Melbourne Researchers