Journal article

CHARACTERIZATION OF MURINE ERYTHROPOIETIN

RL CUTLER, GR JOHNSON, NA NICOLA

EXPERIMENTAL HEMATOLOGY | ELSEVIER SCIENCE INC | Published : 1985

Abstract

Although erythropoietins from human and sheep sources have been purified, a mouse erythropoietin remains essentially uncharacterized despite the fact that the mouse is most commonly used to assay for erythropoietin. Because other murine growth factors may have erythropoietic activity it will be essential to compare these with erythropoietin from murine sources rather than from other species. Here we compare the physicochemical properties and some of the bioactivities of erythropoietins from anemic mouse serum and human urine in parallel fractionations. Both molecules showed similar molecular weights (40-45,000) by gel filtration and similar retention characteristics on reverse-phase high-per..

View full abstract

University of Melbourne Researchers