Specific binding of leukemia inhibitory factor to murine myoblasts in culture

Abstract

Leukemia inhibitory factor (LIF) is a member of the cytokine family of growth factors. It has been shown to exert a variety of actions on a diverse range of cell types, including neuronal, bone, and hemopoietic cells (Hilton, 1992, Trends Biochem. Sci., 17:72–76). In many of these cell types, studies have indicated the presence of specific receptors for LIF (Godard et al., 1982, J. Biol. Chem., 267:3214–3222; Hilton et al., 1988, Proc. Natl. Acad. Sci. USA, 85:5971–5975; Hilton and Nicola, 1992, J. Biol. Chem., 267:10238–10247.). The mechanism by which these receptors act is believed to involve tyrosine phosphorylation and the signal transducing receptor component gp130. We have previously s..