Journal article

SPECIFIC BINDING OF LEUKEMIA INHIBITORY FACTOR TO MURINE MYOBLASTS IN CULTURE

J BOWER, N VAKAKIS, NA NICOLA, L AUSTIN

JOURNAL OF CELLULAR PHYSIOLOGY | WILEY-LISS | Published : 1995

Abstract

Leukemia inhibitory factor (LIF) is a member of the cytokine family of growth factors. It has been shown to exert a variety of actions on a diverse range of cell types, including neuronal, bone, and hemopoietic cells (Hilton, 1992, Trends Biochem. Sci., 17:72-76). In many of these cell types, studies have indicated the presence of specific receptors for LIF (Godard et al., 1982, J. Biol. Chem., 267: 3214-3222; Hilton et al., Proc. Natl. Acad. Sci. USA, 85:5971-5975; Hilton and Nicola, 1992, J. Biol. Chem., 267:10238-10247.). The mechanism by which these receptors act is believed to involve tyrosine phosphorylation and the signal transducing receptor component gp130. We have previously shown ..

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