Journal article

BONE-MARROW CELLS FROM A/J MICE DO NOT PROLIFERATE IN INTERLEUKIN-3 BUT EXPRESS NORMAL NUMBERS OF INTERLEUKIN-3 RECEPTORS

AJ HAPEL, MC FUNG, NK MAK, C MORRIS, D METCALE, N NICOLA

BRITISH JOURNAL OF HAEMATOLOGY | BLACKWELL SCIENCE LTD | Published : 1992

Abstract

Haemopoietic cells from A/J mice do not form colonies (proliferate) in response to interleukin-3 (multi-CSF, IL-3). We have examined different populations of cells from A/J mice and shown that, despite their failure to proliferate in response to IL-3, cells from bone marrow, spleen and the peritoneum all bound 125I-labelled IL-3. A wide variety of cell types bound IL-3 as determined by autoradiography, including promyelocytes, myelocytes, metamyelocytes, polymorphs, promonocytes, monocytes, eosinophils and lymphocytes, but not nucleated erythroid cells, and the proportion of each cell type binding label was similar when cells from A/J mice were compared with those of C57B1/6 and Balb/c mice...

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