Differentiation commitment in normal hemopoiesis and leukemic transformation
D Metcalf, NA Nicola, L Robb
JOURNAL OF CELLULAR PHYSIOLOGY | WILEY-LISS | Published : 1997
Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.