Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region

Abstract

MAMMALIAN sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis (reviewed in ref. 1). Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two doses in both males and females, and escape inactivation of the X chromosome in females. Indirect evidence suggests that there must be several pseudoautosomal genes, and several candidates have been proposed. Until now, the only gene that has been unequivocally located in the PAR is MIC2, which encodes a cell-surface antigen of unknown function2,3. We now rep..