Journal article

THE EXCESS NUMBERS OF PERITONEAL-MACROPHAGES IN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR TRANSGENIC MICE ARE GENERATED BY LOCAL PROLIFERATION

D METCALF, MJ ELLIOTT, NA NICOLA

JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 1992

Abstract

Mice transgenic for the hemopoietic growth factor, granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibit a sustained elevation of GM-CSF levels and a 50-100-fold elevation of peritoneal macrophage cell numbers. The excess cell numbers were found to be generated in pre-adult life, with numbers remaining relatively constant thereafter. In the pre-adult period, no abnormalities were noted in the number or composition of blood, bone marrow, or spleen cells, the type or number of GM progenitor cells in the marrow or spleen, or the rate of appearance of newly formed monocytes in the peripheral blood. Peritoneal macrophages in pre-adult transgenic mice exhibited elevated mitotic activi..

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University of Melbourne Researchers