Urinary alkalinisation with oral sodium bicarbonate for patients at risk of contrast-induced nephropathy

Abstract

Background: Intravenous sodium bicarbonate is used to reduce the risk of contrast-induced nephropathy (CIN). Intravenous sodium bicarbonate is inconvenient and requires inpatient hospital resources, while oral sodium bicarbonate is less costly and easy-to-use. Aim: To determine whether oral sodium bicarbonate has a similar effect on urinary pH as intravenous sodium bicarbonate in patients at risk of CIN. Method: This sequential crossover study was conducted in patients from the cardiology and renal units scheduled for a non-emergency contrast-enhanced procedure. Participants received intravenous sodium bicarbonate 150 mmol/L at 3 mL/ kg/h, 1 hour prior, then 1 mL/kg/h during and for 6 hours ..