Prospective Pilot Trial of Dexmedetomidine Sedation for Awake Diagnostic Flexible Bronchoscopy
Keat Lee, Ruari Orme, Daryl Williams, Reny Segal
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
Dexmedetomidine has the favorable properties of sedation, sympatholysis, analgesia, and a low risk of apnea. These properties suggest that dexmedetomidine may be useful in procedural sedation. In view of this, we conducted a pilot trial to determine the feasibility of using dexmedetomidine as a sole agent for providing sedation during awake diagnostic flexible bronchoscopy. Patients presenting for awake diagnostic flexible bronchoscopy consented to participate in a trial of dexmedetomidine sedation for the procedure. In addition to local anesthetic topicalization of the airways, dexmedetomidine was infused at 0.5 μg/kg over 10 minutes followed by an infusion of 0.2 to 0.7 μg/kg/h titrating t..View full abstract
Hospira Pty Ltd (Australia) provided the trial drug unconditionally with no input into the study design.