Journal article
Clinical calculator for Early mortality in Metastatic colorectal cancer: An analysis of Patients from 28 clinical trials in the aide et recherche en cancérologie digestive database
LA Renfro, RM Goldberg, A Grothey, A Sobrero, R Adams, MT Seymour, V Heinemann, HJ Schmoll, JY Douillard, H Hurwitz, CS Fuchs, E Diaz-Rubio, R Porschen, C Tournigand, B Chibaudel, PM Hoff, FF Kabbinavar, A Falcone, NC Tebbutt, CJA Punt Show all
Journal of Clinical Oncology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Purpose Factors contributing to early mortality after initiation of treatment of metastatic colorectal cancer are poorly understood. Materials and Methods Data from 22,654 patients enrolled in 28 randomized phase III trials contained in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were pooled. Multivariable logistic regression models for 30-, 60-, and 90-day mortality were constructed, including clinically and statistically significant patient and disease factors and interaction terms. A calculator (nomogram) for 90-day mortality was developed and validated internally using bootstrapping methods and externally using a 10% random holdout sample from each trial. The impact ..
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Awarded by National Center for Advancing Translational Sciences
Funding Acknowledgements
Supported by the National Center for Advancing Translational Science Clinical and Translational Science Awards Grant No. KL2 TR000136 and the Aide et Recherche en Cancerologie Digestive Database.