Journal article

Extracellular vesicles for personalized therapy decision support in advanced metastatic cancers and its potential impact for prostate cancer

Carolina Soekmadji, Niall M Corcoran, Irina Oleinikova, Lidija Jovanovic, Grant A Ramm, Colleen C Nelson, Guido Jenster, Pamela J Russell

The Prostate | WILEY | Published : 2017

Abstract

The use of circulating tumor cells (CTCs) and circulating extracellular vesicles (EVs), such as exosomes, as liquid biopsy-derived biomarkers for cancers have been investigated. CTC enumeration using the CellSearch based platform provides an accurate insight on overall survival where higher CTC counts indicate poor prognosis for patients with advanced metastatic cancer. EVs provide information based on their lipid, protein, and nucleic acid content and can be isolated from biofluids and analyzed from a relatively small volume, providing a routine and non-invasive modality to monitor disease progression. Our pilot experiment by assessing the level of two subpopulations of small EVs, the CD9 p..

View full abstract

Grants

Awarded by U.S. Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Idea Development New Investigator Award


Awarded by U.S. Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Postdoctoral Training Award


Funding Acknowledgements

Movember Foundation GAP1 Exosomes U.S.; U.S. Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Idea Development New Investigator Award, Grant number: W81XWH-16-1-0736; U.S. Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Postdoctoral Training Award, Grant number: W81XWH-12-1-0047