Functional effects of unilateral open-angle glaucoma on the primary and extrastriate visual cortex
Victor M Borges, Helen V Danesh-Meyer, Joanna M Black, Benjamin Thompson
JOURNAL OF VISION | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2015
The purpose of this study was to use functional magnetic resonance imaging (fMRI) to investigate the response of the visual cortex to unilateral primary open-angle glaucoma (POAG). Specifically, we assessed whether regions of V1 and V2 with lost input from the glaucomatous eye had a greater response to input from the nonaffected fellow eye. Nine participants with unilateral POAG causing paracentral visual field defects and four controls participated in the study. We found no evidence for an increased response to the fellow eye in glaucoma-affected regions of the visual cortex; however, in agreement with previous studies, there was a pronounced, retinotopically localized reduction of activati..View full abstract
This study was funded by the Neurological Foundation of New Zealand, the Auckland Medical Research Foundation, and the Stevenson Trust. The authors thank Ayton Hope, Maurice Moriarty, Jeremy Morrison, and the Trinity MRI team for their support and expertise.