Journal article

Gap junction proteins in the light-damaged albino rat

Cindy X Guo, Tran Henry, Colin R Green, Helen V Danesh-Meyer, Monica L Acosta



PURPOSE: Changes in connexin expression are associated with many pathological conditions seen in animal models and in humans. We hypothesized that gap junctions are important mediators in tissue dysfunction and injury processes in the retina, and therefore, we investigated the pattern of connexin protein expression in the light-damaged albino rat eye. METHODS: Adult Sprague-Dawley rats were exposed to intense light for 24 h. The animals were euthanized, and ocular tissue was harvested at 0 h, 6 h, 24 h, 48 h, and 7 days after light damage. The tissues were processed for immunohistochemistry and western blotting to analyze the expression of the gap junction proteins in the light-damaged condi..

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Awarded by Health Research Council of New Zealand

Awarded by Auckland Medical Research Foundation

Awarded by Faculty Research Development Fund

Funding Acknowledgements

Grant information: This work was supported in part by the Health Research Council of New Zealand, reference number: 09/157; 2) Auckland Medical Research Foundation, reference number: 1109007; 3) Faculty Research Development Fund, reference number: 3624490.