Gap junction proteins in the light-damaged albino rat
Cindy X Guo, Tran Henry, Colin R Green, Helen V Danesh-Meyer, Monica L Acosta
MOLECULAR VISION | MOLECULAR VISION | Published : 2014
PURPOSE: Changes in connexin expression are associated with many pathological conditions seen in animal models and in humans. We hypothesized that gap junctions are important mediators in tissue dysfunction and injury processes in the retina, and therefore, we investigated the pattern of connexin protein expression in the light-damaged albino rat eye. METHODS: Adult Sprague-Dawley rats were exposed to intense light for 24 h. The animals were euthanized, and ocular tissue was harvested at 0 h, 6 h, 24 h, 48 h, and 7 days after light damage. The tissues were processed for immunohistochemistry and western blotting to analyze the expression of the gap junction proteins in the light-damaged condi..View full abstract
Awarded by Health Research Council of New Zealand
Awarded by Auckland Medical Research Foundation
Awarded by Faculty Research Development Fund
Grant information: This work was supported in part by the Health Research Council of New Zealand, reference number: 09/157; 2) Auckland Medical Research Foundation, reference number: 1109007; 3) Faculty Research Development Fund, reference number: 3624490.