Journal article

The pharmacokinetics of esmolol in pediatric subjects with supraventricular arrhythmias.

Peter C Adamson, Larry A Rhodes, J Philip Saul, MacDonald Dick, Michael R Epstein, Peter Moate, Raymond Boston, Mark S Schreiner

Pediatr Cardiol | Published : 2006

Abstract

Esmolol is often used in the acute management of children with arrhythmias and/or hypertension; however, pharmacokinetic studies of the drug in children have been limited. The objective of this study was to determine the pharmacokinetics of esmolol in children with a history of supraventricular arrhythmias (SVT) who were scheduled for diagnostic electrophysiology study or a catheter ablation procedure. Subjects were stratified into two age groups: 2-11 and 12-16 years. After an episode of stimulated or spontaneous SVT, esmolol was administered intravenously as a 1,000 microg/kg bolus followed by continuous infusion at 300 microg/kg/min. Blood samples were collected before, at 5, 10 and 15 mi..

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University of Melbourne Researchers