Journal article

A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge.

Ray C Boston, Peter J Moate

Am J Physiol Regul Integr Comp Physiol | Published : 2008


Dynamics of nonesterified fatty acid (NEFA) metabolism in humans requires quantification if we are to understand the etiology of such diseases as type 1 and 2 diabetes, as well as metabolic syndrome and obesity, or if we are to elucidate the mechanism of action of various interventions. We present a new compartmental model that employs the pattern of plasma glucose concentrations in healthy young adults to predict dynamic changes that occur in plasma NEFA concentrations during either a glucose-only intravenous glucose tolerance test, or an insulin-modified intravenous tolerance test, or a modified protocol during which variable-rate glucose infusions were administered to prevent plasma gluco..

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University of Melbourne Researchers