Journal article

Additivity in the Analysis and Design of HIV Protease Inhibitors

Robert N Jorissen, GS Kiran Kumar Reddy, Akbar Ali, Michael D Altman, Sripriya Chellappan, Saima G Anjum, Bruce Tidor, Celia A Schiffer, Tariq M Rana, Michael K Gilson

Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2009

University of Melbourne Researchers

Grants

Awarded by National Institute of General Medical Sciences (NIGMS) of the NIH


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

We thank Dr. Madhavi Nalam for sharing crystal structures prior to publication and Dr. Stine Peterson for pointing out that our additivity analysis "reinvented the wheel" first devised by Free and Wilson. A generous gift of chiral epoxides from Kaneka USA is gratefully acknowledged. This publication was made possible by grants nos. GM066524 and GM061300 from the National Institute of General Medical Sciences (NIGMS) of the NIH. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIGMS.