Additivity in the Analysis and Design of HIV Protease Inhibitors
Robert N Jorissen, GS Kiran Kumar Reddy, Akbar Ali, Michael D Altman, Sripriya Chellappan, Saima G Anjum, Bruce Tidor, Celia A Schiffer, Tariq M Rana, Michael K Gilson
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2009
Awarded by National Institute of General Medical Sciences (NIGMS) of the NIH
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
We thank Dr. Madhavi Nalam for sharing crystal structures prior to publication and Dr. Stine Peterson for pointing out that our additivity analysis "reinvented the wheel" first devised by Free and Wilson. A generous gift of chiral epoxides from Kaneka USA is gratefully acknowledged. This publication was made possible by grants nos. GM066524 and GM061300 from the National Institute of General Medical Sciences (NIGMS) of the NIH. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIGMS.