Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
Nanthini Jayabalan, Soumyalekshmi Nair, Zarin Nuzhat, Gregory E Rice, Felipe A Zuniga, Luis Sobrevia, Andrea Leiva, Carlos Sanhueza, Jaime Agustin Gutierrez, Martha Lappas, Dilys Jane Freeman, Carlos Salomon
FRONTIERS IN ENDOCRINOLOGY | FRONTIERS MEDIA SA | Published : 2017
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Excess energy storage is predominantly regulated by the adipose tissue. Primarily made up of adipocytes, adipose tissue acts as the body's major energy reservoir. The role of adipose tissue, however, is not restricted to a "bag of fat." The adipose tissue is an endocrine organ, secreting various ..View full abstract
Awarded by Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
This study was supported by Lions Medical Research Foundation, UQ-Ochsner Seed Fund for Collaborative Research, The University of Queensland, Faculty of Medicine M + BS Emerging Leaders Medical Research Grant, and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1170809 and 1150377).