Review: Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus.
Juvita D Iljas, Dominic Guanzon, Omar Elfeky, Gregory E Rice, Carlos Salomon
Placenta | Published : 2017
Analysis of the human genome revealed that only 1.2% encoded for proteins, which raised questions regarding the biological significance of the remaining genome. We now know that approximately 80% of the genome serves at least one biochemical function within the cell. A portion of this 80% consists of a family of non-coding regulatory RNAs, one important member being microRNAs (miRNAs). miRNAs can be detected in tissues and biofluids, where miRNAs in the latter can be bound to proteins or encapsulated within lipid vesicles such as exosomes. Gestational diabetes mellitus (GDM) is a complication of pregnancy, which has harmful health impacts on both the fetus as well as the mother. The incidenc..View full abstract