The longitudinal association between inflammation and incident depressive symptoms in men: The effects of hs-CRP are independent of abdominal obesity and metabolic disturbances

Abstract

Background: This cohort study evaluates whether the association between low-grade inflammation and incident depressive symptoms is independent of abdominal obesity and metabolic disturbances. Methods: A cohort of 1167 non-depressed men aged 35 to 80 years were followed up over 5 years to assess incident depressive symptoms measured by the Centre for Epidemiology Scale-Depression or Beck Depression Inventory-I. Venous tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and high sensitivity C-reactive protein (hsCRP) were quantified at baseline and 5 years. Logistic regression determined whether hsCRP, IL-6 and TNF-α were associated with incident depressive symptoms independent of abdominal ..