Journal article
Longitudinal sequence and functional evolution within glycoprotein E2 in hepatitis C virus genotype 3a infection
YMO Alhammad, S Maharajh, R Butcher, JS Eden, PA White, P Poumbourios, HE Drummer
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Open access
Abstract
The E2 glycoprotein of Hepatitis C virus (HCV) is a major target of the neutralizing antibody (NAb) response with the majority of epitopes located within its receptor binding domain (RBD; 384-661). Within E2 are three variable regions located at the N-terminus (HVR1; 384-411), and internally at 460-480 (HVR2) and 570-580 [intergenotypic variable region (igVR)], all of which lie outside a conserved core domain that contains the CD81 binding site, essential for attachment of virions to host cells and a major target of NAbs. In this study, we examined the evolution of the E1 and E2 region in two patients infected with genotype 3a virus. Whereas one patient was able to clear the acute infection,..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council project grant APP1020175. HED is currently supported by National Health and Medical Research Council fellowship 1041897, and previously 433913. J-SE is supported by a National Health and Medical Research Council fellowship 1073466. The ATAHC Study was funded by the National Institute on Drug Abuse of the National Institutes of Health (NIH) under award RO1 DA 15999. SFDC 03848796.