Journal article

Intrathecal melanin-concentrating hormone reduces sympathetic tone and blocks cardiovascular reflexes

Eyitemi J Egwuenu, Angelina Y Fong, Paul M Pilowsky

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2012


Melanin-concentrating hormone (MCH) is a neuropeptide that acts to increase feeding behavior and decrease energy expenditure. The role of MCH in central cardiorespiratory regulation is still poorly understood. Experiments were conducted on urethane-anesthetized, vagotomized, and artificially ventilated male Sprague-Dawley rats (n = 22) to ascertain whether MCH modulates sympathetic vasomotor tone, as well as barosympathetic, chemosympathetic, and somatosympathetic reflexes at the level of the spinal cord. Intrathecal injection of 10 μl of MCH produced a dose-dependent hypotension, bradycardia, and sympathoinhibition. Peak response was observed following administration of 1 mM MCH, causing a ..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

This work is supported by grants from the National Health and Medical Research Council of Australia (1024489), the Australian Research Council (DP110102110), Macquarie University and the National Heart Foundation of Australia (G-11S-5957). E. Egwuenu is supported by a Macquarie Research Excellence Scholarship.