Intrathecal melanin-concentrating hormone reduces sympathetic tone and blocks cardiovascular reflexes
Eyitemi J Egwuenu, Angelina Y Fong, Paul M Pilowsky
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2012
Melanin-concentrating hormone (MCH) is a neuropeptide that acts to increase feeding behavior and decrease energy expenditure. The role of MCH in central cardiorespiratory regulation is still poorly understood. Experiments were conducted on urethane-anesthetized, vagotomized, and artificially ventilated male Sprague-Dawley rats (n = 22) to ascertain whether MCH modulates sympathetic vasomotor tone, as well as barosympathetic, chemosympathetic, and somatosympathetic reflexes at the level of the spinal cord. Intrathecal injection of 10 μl of MCH produced a dose-dependent hypotension, bradycardia, and sympathoinhibition. Peak response was observed following administration of 1 mM MCH, causing a ..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
Awarded by National Heart Foundation of Australia
This work is supported by grants from the National Health and Medical Research Council of Australia (1024489), the Australian Research Council (DP110102110), Macquarie University and the National Heart Foundation of Australia (G-11S-5957). E. Egwuenu is supported by a Macquarie Research Excellence Scholarship.