Journal article
Vasostatin I (CgA 17-76) vasoconstricts rat splanchnic vascular bed but does not affect central cardiovascular function
AA Rahman, IZ Shahid, AY Fong, AM Hammond, PM Pilowsky
Autonomic Neuroscience Basic and Clinical | ELSEVIER SCIENCE BV | Published : 2012
Abstract
Vasostatin I (CgA 1-76) is a naturally occurring biologically active peptide derived from chromogranin A (CgA), and is so named for its inhibitory effects on vascular tension. CgA mRNA is expressed abundantly in sympathoexcitatory catecholaminergic neurons of the rostral ventrolateral medulla (RVLM). CgA microinjection into the RVLM decreases blood pressure (BP), heart rate (HR) and sympathetic nerve activity (SNA). Proteolytic fragments of CgA are thought to be responsible for the cardiovascular effects observed. We hypothesised that vasostatin I is one of the fragments responsible for the central effects of CgA. We examined the role of a vasostatin I fragment, CgA 17-76 (VS-I (CgA17-76)), ..
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Awarded by Appalachian Regional Commission
Funding Acknowledgements
Work in the Authors' laboratory is supported by grants from the National Health and Medical Research Council of Australia (457080, 457069), ARC (DP110102110), Macquarie University and the Garnett Passe and Rodney Williams Memorial Foundation. A.A.R. and I.Z.S. are recipients of Macquarie Research Excellence Scholarships. AMH is supported by a Coregas-Macquarie Research Excellence Scholarship. The authors have no conflicts of interest to declare.