Journal article

The contrasting roles of Th17 immunity in human health and disease

Edwin Hoe, Jeremy Anderson, Jordan Nathanielsz, Zheng Quan Toh, Rachel Marimla, Anne Balloch, Paul V Licciardi

MICROBIOLOGY AND IMMUNOLOGY | WILEY | Published : 2017

Abstract

The human immune system is a tightly regulated network that protects the host from disease. An important aspect of this is the balance between pro-inflammatory Th17 cells and anti-inflammatory T regulatory (Treg) cells in maintaining immune homeostasis. Foxp3+ Treg are critical for sustaining immune tolerance through IL-10 and transforming growth factor-β while related orphan receptor-γt+ Th17 cells promote immunopathology and auto-inflammatory diseases through the actions of IL-17A, IL-21 and IL-22. Therefore, imbalance between Treg and Th17 cells can result in serious pathology in many organs and tissues. Recently, certain IL-17-producing cells have been found to be protective against infe..

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