Journal article

In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts

King-Hwa Ling, Peter J Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M Mattiske, Jeffrey R Mann, David L Adelson, Paul Q Thomas, Christopher N Hahn, Hamish S Scott

Data in Brief | ELSEVIER SCIENCE BV | Published : 2016

Abstract

SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function ..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council


Awarded by Malaysian Ministry of Science, Technology & Innovation (MOSTI) Science fund


Awarded by Malaysian Ministry of Higher Education Fundamental Research Grant Scheme


Funding Acknowledgements

This work was supported by National Health and Medical Research Council fellowships [171601 and 461204 to H.S.S.], National Health and Medical Research Council Grants [219176, 257501 and 257529 to H.S.S.], Malaysian Ministry of Science, Technology & Innovation (MOSTI) Science fund (02-01-04-SF2336 to K.H.L.), Malaysian Ministry of Higher Education Fundamental Research Grant Scheme (04-01-15-1663FR to P.S.C.), and a fellowship from Pfizer Australia [to P.Q.T.]. M.P.-Y.L., J.-W.L., H.-C.L. and S.Z.A. were recipients of the Malaysian Ministry of Higher Education MyBrain Scholarship.