β-Adrenoceptor agonists and antagonists: conformational analysis of the ethanolamine and propanolamine side-chain

Abstract

The solid state conformations of the ethanolamine or propanolamine side-chain for a variety of β-adrenoceptor agonists and antagonists have been analysed and compared to those conformations determined in solution and theoretical gas states. For the arylethanolamine (AEA)-type compounds the ethanolamine side-chain conformations adopted in the solid state were found to be independent of pharmacological action, crystallization method or substitution on the phenyl ring and arnino groups. Common conformations were observed in the solid, theoretical gas and solution states. This was also the case for the propanolamine side-chain of aryloxypropanolamine (AOPA)-type compounds. The propanolamine side..