Journal article

Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL-monocyte interactions

Steffen U Eisenhardt, Julia Starke, Jan R Thiele, Andrew Murphy, G Bjoern Stark, Nicole Bassler, Dmitri Sviridov, Karl Winkler, Karlheinz Peter

Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2012

Abstract

Previous studies have reported that C-reactive protein (CRP) interacting with low-density lipoproteins (LDL) affects macrophage activation and LDL uptake. However, the physiological relevance of CRP-LDL interaction with circulating monocytes remains elusive. Moreover, recent studies have shown that CRP exists in two isoforms with partly opposing characteristics pentameric (pCRP) and monomeric CRP (mCRP). Here we investigated the effects of CRP interacting with minimally modified low-density lipoprotein (mmLDL) interaction in regard to events involved in formation of atherosclerotic plaque. We analyzed the effect of mmLDL on human monocytes and found a substantial increase in monocyte activat..

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