Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL-monocyte interactions
Steffen U Eisenhardt, Julia Starke, Jan R Thiele, Andrew Murphy, G Bjoern Stark, Nicole Bassler, Dmitri Sviridov, Karl Winkler, Karlheinz Peter
Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2012
Previous studies have reported that C-reactive protein (CRP) interacting with low-density lipoproteins (LDL) affects macrophage activation and LDL uptake. However, the physiological relevance of CRP-LDL interaction with circulating monocytes remains elusive. Moreover, recent studies have shown that CRP exists in two isoforms with partly opposing characteristics pentameric (pCRP) and monomeric CRP (mCRP). Here we investigated the effects of CRP interacting with minimally modified low-density lipoprotein (mmLDL) interaction in regard to events involved in formation of atherosclerotic plaque. We analyzed the effect of mmLDL on human monocytes and found a substantial increase in monocyte activat..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by German Research Foundation (DFG)
SUE was supported by a National Health and Medical Research Council (NHMRC) project grant # 472666, and a grant from the German Research Foundation (DFG) # EI 866/1-1, KP is a future fellow of the Australian Research Council.