Journal article
IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection
I Sebina, KR James, MSF Soon, LG Fogg, SE Best, FD Labastida Rivera, M Montes de Oca, FH Amante, BS Thomas, L Beattie, F Souza-Fonseca-Guimaraes, MJ Smyth, PJ Hertzog, GR Hill, A Hutloff, CR Engwerda, A Haque
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2016
Open access
Abstract
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many months for naturally-exposed individuals to develop robust humoral immunity. Explanations for this have focused on antigenic variation by Plasmodium, but have considered less whether host production of parasite-specific antibody is sub-optimal. In particular, it is unclear whether host immune factors might limit antibody responses. Here, we explored the effect of Type I Interferon signalling via IFNAR1 on CD4+ T-cell and B-cell responses in two non-lethal murine models of malaria, P. chabaudi chabaudi AS (PcAS) and P. yoelii 17XNL (Py17XNL) infection. Firstly, we ..
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Awarded by Australian National Health & Medical Research Council (NHMRC)
Funding Acknowledgements
This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC). IS was supported by The University of Queensland Centennial and IPRS Scholarships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.