Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
Lynette Beattie, Amy Sawtell, Jason Mann, Teija CM Frame, Bianca Teal, Fabian de Labastida Rivera, Najmeeyah Brown, Katherine Walwyn-Brown, John WJ Moore, Sandy MacDonald, Eng-Kiat Lim, Jane E Dalton, Christian R Engwerda, Kelli P MacDonald, Paul M Kaye
Journal of Hepatology | ELSEVIER | Published : 2016
BACKGROUND & AIMS: Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of pathogens and other particulate materials that reach the systemic circulation. Recent studies have identified KCs as a yolk sac-derived resident macrophage population that is replenished independently of monocytes in the steady state. Although it is now established that following local tissue injury, bone marrow derived monocytes may infiltrate the tissue and differentiate into macrophages, the extent to which newly differentiated macrophages functionally resemble the KCs they have replaced has not been extensively studied. METHODS: We studied the two populations of K..View full abstract
Awarded by UK Medical Research Council
Awarded by Australian National Health and Medical Research Council
Awarded by Medical Research Council
This work was funded by the UK Medical Research Council (Grant #G0802620) and the Australian National Health and Medical Research Council (Grant #APP1105817).