Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4( ) T Cell Responses Enhances Antiparasitic Immunity
Ashraful Haque, Amanda C Stanley, Fiona H Amante, Fabian de Labastida Rivera, YongHong Zhou, Rachel D Kuns, Vanessa Yardley, Shimon Sakaguchi, Geoffrey R Hill, Christian R Engwerda
The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2010
Chronic infectious diseases and cancers are often associated with suboptimal effector T cell responses. Enhancement of T cell costimulatory signals has been extensively studied for cancer immunotherapy but not so for the treatment of infectious disease. The few previous attempts at this strategy using infection models have lacked cellular specificity, with major immunoregulatory mechanisms or innate immune cells also being targeted. In this study, we examined the potential of promoting T cell responses via the glucocorticoid-induced TNF receptor (GITR) family-related protein in a murine model of visceral leishmaniasis. GITR stimulation during established infection markedly improved antiparas..View full abstract
This work was supported by grants from the Australian National Health and Medical Research Council.