Short- and long-term effects of risperidone on catalepsy sensitisation and acquisition of conditioned avoidance response: Adolescent vs adult rats
Aung Aung Kywe Moe, Gregory A Medely, Timothy Reeks, Thomas HJ Burne, Darryl W Eyles
Pharmacological Research | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017
The effects of antipsychotic drugs (APDs) on the adolescent brain are poorly understood despite a dramatic increase in prescription of these drugs in adolescents over the past twenty years. Neuronal systems continue to be remodeled during adolescence. Therefore, when given in adolescence, antipsychotic drugs (APDs) have the potential to affect this remodeling. In this study we investigated the effects of chronic 22-day risperidone treatment (1.3mg/kg/day) in both adolescent and adult rats. We examined short- and long-term changes in behaviour (catalepsy, locomotion and conditioned avoidance response (CAR)), and dopaminergic and serotonergic neurochemistry in the striatum and the nucleus accu..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) Australia
Financial support was provided by National Health and Medical Research Council (NHMRC) Australia grant APP1042259 to DE and TB and The University of Queensland International PhD scholarship to AAKM. The funding organizations did not have any roles in the design and conduct of the study, interpretation of data or writing of the manuscript. The authors would like to thank Mrs. Suzy Alexander for her support with experimental logistics.