Effect of haemodialysis and residual renal function on serum levels of galectin-3, B-type natriuretic peptides and cardiac troponin T
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
NEPHROLOGY | WILEY | Published : 2018
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (high-sensitivity troponin T (hs-TnT)) are affected by haemodialysis, residual renal function (RRF) and cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post-haemodialysis then echocardiography and inter-dialytic urine collection to calculate RRF (mL/min per 1.73m2 ) and urine output (mL/day). Galectin-3, BNP-32, NT-ProBNP and hs-TnT levels were compared across tertiles of echocardiographic parameters, R..View full abstract
This work was supported by a Don and Lorraine Jacquot Fellowship for 2008, and an Austin Medical Research Foundation grant (2008). Abbott Diagnostics (Australia) provided the galectin-3 assay kits that were used in this study. The authors declare that no conflict of interests exists.