Journal article
Sustained malaria control over an 8-year period in Papua New Guinea: The challenge of low-density asymptomatic plasmodium infections
C Koepfli, M Ome-Kaius, S Jally, E Malau, S Maripal, J Ginny, L Timinao, JH Kattenberg, T Obadia, M White, P Rarau, N Senn, AE Barry, JW Kazura, I Mueller, LJ Robinson
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017
Abstract
Background. Te scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. Te effects on the proportions of asymptomatic and submicroscopic infections and on transmission potential are yet poorly understood. Methods. In Papua New Guinea, vector control has been intensifed since 2008, and improved diagnosis and treatment was introduced in 2012. Cross-sectional surveys were conducted in Madang Province in 2006 (with 1280 survey participants), 2010 (with 2117 participants), and 2014 (with 2516 participants). Infections were quantifed by highly sensitive quantitative polymerase chain reaction (PCR) analysi..
View full abstractGrants
Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by the International Centers of Excellence for Malaria Research (grant U19 AI089686), the TransEPI consortium, funded by the Bill and Melinda Gates Foundation; the NHMRC (grant 1021544; early career fellowship 1016443 to L. J. R.); the Victorian State Government, through operational infrastructure support; the Australian Government NHMRC IRIISS; the Swiss National Science Foundation (fellowship P2BSP3_151880 to C. K.); the Medical Research Council (population health scientist fellowship to M. W.); and the NHMRC (senior research fellowship to I. M.).