Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group

S Kelly; N Jahanshad; A Zalesky; P Kochunov; I Agartz; C Alloza; OA Andreassen; C Arango; N Banaj; S Bouix; CA Bousman; RM Brouwer; J Bruggemann; J Bustillo; W Cahn; V Calhoun; D Cannon; V Carr; S Catts; J Chen; JX Chen; X Chen; C Chiapponi; KK Cho; V Ciullo; AS Corvin; B Crespo-Facorro; V Cropley; P De Rossi; CM Diaz-Caneja; EW Dickie; S Ehrlich; FM Fan; J Faskowitz; H Fatouros-Bergman; L Flyckt; JM Ford; JP Fouche; M Fukunaga; M Gill; DC Glahn; R Gollub; ED Goudzwaard; H Guo; RE Gur; RC Gur; TP Gurholt; R Hashimoto; SN Hatton; FA Henskens; DP Hibar; IB Hickie; LE Hong; J Horacek; FM Howells; HE Hulshoff Pol; CL Hyde; D Isaev; A Jablensky; PR Jansen; J Janssen; EG Jönsson; LA Jung; RS Kahn; Z Kikinis; K Liu; P Klauser; C Knöchel; M Kubicki; J Lagopoulos; C Langen; S Lawrie; RK Lenroot; KO Lim; C Lopez-Jaramillo; A Lyall; V Magnotta; RCW Mandl; DH Mathalon; RW McCarley; S McCarthy-Jones; C McDonald; S McEwen; A McIntosh; T Melicher; RI Mesholam-Gately; PT Michie; B Mowry; BA Mueller; DT Newell; P O'Donnell; V Oertel-Knöchel; L Oestreich; SA Paciga; C Pantelis; O Pasternak; G Pearlson; GR Pellicano; A Pereira; J Pineda Zapata

Journal article

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group

S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, OA Andreassen, C Arango, N Banaj, S Bouix, CA Bousman, RM Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen Show all

Molecular Psychiatry | SPRINGERNATURE | Published : 2018

DOI: 10.1038/mp.2017.170

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Abstract

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia p..

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University of Melbourne Researchers

Andrew Zalesky Author

Vanessa Cropley Author

Paul Klauser Author

Christos Pantelis Author

Grants

Awarded by NSW Ministry of Health

Funding Acknowledgements

Acknowledgments, funding sources, conflict of interest and author contributions can be found in Supplementary Note 8. GD's research is generously supported by the European Research Council (grant no. 677467). CSW is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079).